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December 18, 2008

6 medical myths debunked - just in time for the holidays

Scientificblogging, drawing on apparently credible medical expertise, deflates six common med myths.

My wife will love this. I've cited #4 to her a million times.

6 Medical Myths Debunked For Christmas:

1. Sugar makes kids hyperactive.

2. Suicides increase over the holidays.

3. Poinsettias are toxic.

4. You lose most of your body heat through your head.

5. Eating at night makes you fat.

6. You can cure a hangover with%u2026

Great fodder for Christmas parties.

Encouraging sign that government may be going all empirical on us

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Atop other Obama appointments, this is one I suspect America's scientists will welcome. From the Washington Post:

Report: Holdren to Lead White House Science Policy

By Joel Achenbach

President-elect Obama will announce this weekend that he has selected physicist John Holdren, who has devoted much of his career to energy and environmental research, as his White House science adviser, according to a published report today.

The Obama transition office would not confirm Holdren's selection. Last night, asked by The Post to comment on the science adviser search, Holdren responded by e-mail that he would be unable to comment because of his work with the Obama transition team.

The report today appeared online at ScienceInsider, a news blog published by the American Association for the Advancement of Science. Holdren served as president of AAAS in 2006.

More at Politico.com, Science, and Discover, and Dot Earth.

December 16, 2008

Zimmer on brain-changing parasites

Good stuff from Zimmer:

You go for a swim, and you don't even notice the tiny worm that burrows into your skin. It slips into a vein and surges along through the blood for a while. Eventually it leaves your blood vessels and starts creeping up your spinal cord. Creep creep creep, it goes, until it reaches your head. It curls up on the surface of your brain, forming a hard cyst. But it is not alone%u2013every time you've gone for swim, worms have slithered into you, and now there are thousands of cysts peppering your brain.

And they are all making drugs that are seeping into your neurons. These drugs are a bit like Prozac, except far more sophisticated. They target certain neurons in certain parts of the brain, altering your behavior surgically, without unwanted side effects.

You don't know what's happening to you. But in situations in which you'd expect to feel scared or stressed, you just want to race around. You whirl in circles, doing whatever is necessary to get the attention of the very thing that terrifies you. Thanks to your uncontrollable flailing, that terror finds you, and you are destroyed.

This is how I imagine you'd feel if you were a fish infected by a parasitic worm called Euhaplorchis californiensis.

Tierney asks: Science or Garbage

A teacher in West Virginia rallied her students to fight to keep the right to recycle -- presumably for the civic (and eco) learning experience. John Tierney argues she's missing a better teaching opportunity:

If we want our children to be scientifically literate and get good jobs in the future, why are we spending precious hours in school teaching them to be garbage collectors?

That’s the question that occurred to me after reading about the second-graders in West Virginia who fought for the right to keep recycling trash even after it became so uneconomical that public officials tried to stop the program. As my colleague Kate Galbraith reports, their teacher was proud of them for all the time they spent campaigning to keep the recycling program alive.

My colleague Andy Revkin suggests that the West Virginia students might be learning something useful about the interplay of economics and ecology, but I fear they and their teacher have missed the lesson


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December 15, 2008

Antidepressant toll on sex worse than thought

As time goes on, it seems the benefits offered by modern antidepressants seem to drop while the downsides seem to expand. A story in today's Boston Globe -- excerpted below -- suggests that up to half of people who take SSRIs suffer significant sexual side-effects.

Sexual "numbness." Lack of libido. Arousal that stalls.

Such sexual symptoms have long been known side effects of the popular Prozac class of antidepressants, but a growing body of research suggests that they are far more common than previously thought, perhaps affecting half or more of patients....

Current warnings on the labels of selective serotonin reuptake inhibitors, or SSRIs, cite early studies in which the prevalence of sexual side effects was lower: 4 percent for Prozac, for example, and ranging from 0 to 28 percent for Paxil.

But more recent studies, in which patients were more likely to be asked about specific sexual side effects and thus more likely to report them, suggest that the ballpark range of those affected by SSRIs is between 30 percent and 50 percent, said researchers including Dr. Richard Balon, a psychiatry professor at Wayne State University who studies the symptoms.

That would translate into millions of affected sex lives among the estimated 1 in 8 American adults who have tried these antidepressants in the past decade or so. Some studies have found the range still higher.

Why the rising costs and flattening benefits? Among other things, it's becoming clear, as the wide use of these drugs runs through time, that many drugs prove less effective and more troublesome when prescribed to sick people (many of whom have other health problems and take other drugs) than when used in clinical trials, which usually take care to use patients with fewer problems. It doesn't help that drug companies often fail to report or publish their less flattering results -- and that they didn't investigate the sexual side-effects more aggressively during the trials.

In this case the differences between side effects in trials and in real life is startling, both for the scale of the difference and, of course, for the high-impact nature of sexual side-effects. As Aline Zoldbrod, a Lexington psychologist and sex therapist quoted in the Globe article notes:

"This is such an upsetting issue. There are people for whom SSRIs are really life-saving, I think, but the idea that someone would have to choose between getting out of the darkness of depression and having a good sex life is horrible."

Hat tip: The ever-watchful Furious Seasons

December 10, 2008

Why we still need newspapers

From Knight Science Journalism Tracker:

Phil. Inquirer: Four part series disembowels the Bush White House version of the EPA

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Many reporters have dived pretty deep into the legal and regulatory changes wrought at the EPA in the last eight years and into the scientist-administrator Stephen Johnson who imposed them at the behest of the George W. Bush administration... But no other newspaper that the Tracker knows of has torn into the agency with as thorough, focussed and full-hearted a pummeling as seen in the Philadelphia Inquirer for four days this week. ....

Sometimes it’s good to let one’s anger show and these reporters do. The pace, enthusiasm, and rhythm of the prose is like that of a flogging of a misbehaving crewman in an old Royal Navy sailing ship.

Oh, that Lucky Jack should have such luck.

November 24, 2008

Who's Driving the Psych Bus? [was 'Psychiatry at a crossroads']

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Sen. Charles Grassley, R-Iowa

As the Times reported Friday, Senator Charles Grassley's pharma-money sweep has taken down another huge player in psychiatry: Grassley revealed that Fred Goodwin, a former NIH director who has long hosted the award-winning NPR radio show "The Infinite Mind," which frequently examined controversies about psychopharmacology, had taken in over $1.3 million consulting and speaking fees from Big Pharma between 2000 and 2007 and failed to report that income to the show's listeners and, apparently, to its producers. (For rundowns on this, see Furious Seasons, Huffington Post, WSJ's Health Blog, PsychCentraol, and PharmaLot

The expansion of Grassley's investigation into journalism throws a new kind of light on the lines through which Big Pharma seeks to shape opinion about powerful psychopharmaceuticals. And the mounting body count from Grassley's campaign -- and the fear in psych departments across the country -- adds to the sense that psychiatry stands near some sort of crisis point.

A Bit o' Background

Goodwin's reported $1.3 million in pharma income is an iceberg the tip of which was exposed in May in a Slate article by Shannon Brownlee and Jeanne Lenzer; I wrote about that article -- and about the counterattack it produced from Pharma and Infinite Mind producer Bill Lichtenstein - in an article at Columbia Journalism Review's science blog. As I noted then, Lichtenstein's counterattack, which seemed to treat failure to disclose conflicts as a hassle that is optional, ignored that drug-industry-related conflicts of interest in psychiatry have have become so big a problem that they are central and relevant to any discussion of any psychiatric disorder.

If journalists like Lichtenstein want the information they present to the public to be taken as credible, they need to err on the side of transparency, presenting not only the voices, but also the relevant financial interests of the experts they feature. Failing to do so only damages message and messenger alike. In the wake of the repeated scandals about drug-company concealment of drug-trial data, it’s strange that I have to spell this out.

Not Getting It

This same tone deafness saturated Goodwin's reported response to Grassley's revelations. If the Times quoted Goodwin accurately, he argued that he suffered no conflict of interest because the various payments from different drug companies "cancelled each other out" -- as if the only concern was whether a particular company, rather than an entire industry, might win his favor.

Continue reading "Who's Driving the Psych Bus? [was 'Psychiatry at a crossroads']" »

October 17, 2008

The Science of Gossip, in Scientific American

In "The Gregarious Brain," my NY Times Magazine story last year about Williams syndrome -- in which a genetic accident causes an intriguing combination of cognitive deficits and hypersociability colored by a lack of social fear and (to some extent) savvy -- I devoted some space to the "social brain" theory," which holds that we humans developed our big brains -- and perhaps language itself -- primarily to manage the complex social dynamics that went with living in large groups. By this figuring, managing social relationships is the most demanding task we face -- and gossip is our primary way of creating, maintaining, and evaluating social relationships and of understanding and managing the complex and ever-changing social networks and relations that largely determine our fates.

From that story:


Understanding one another, it seems, is our greatest cognitive challenge. And the only way humans could handle groups of more than 50, Dunbar suggests, was to learn how to talk.

“The conventional view,” Dunbar notes in his book “Grooming, Gossip and the Evolution of Language,” “is that language evolved to enable males to do things like coordinate hunts more effectively. . . . I am suggesting that language evolved to allow us to gossip.”

Dunbar’s assertion about the origin of language is controversial. But you needn’t agree with it to see that talk provides a far more powerful and efficient way to exchange social information than grooming does. In the social-brain theory’s broad definition, gossip means any conversation about social relationships: who did what to whom, who is what to whom, at every level, from family to work or school group to global politics. Defined this way, gossip accounts for about two-thirds of our conversation. All this yakking — murmured asides in the kitchen, gripefests in the office coffee room — yields vital data about changing alliances; shocking machinations; new, wished-for and missed opportunities; falling kings and rising stars; dangerous rivals and potential friends. These conversations tell us too what our gossipmates think about it all, and about us, all of which is crucial to maintaining our own alliances.

For we are all gossiped about, constantly evaluated by two criteria: Whether we can contribute, and whether we can be trusted. This reflects what Ralph Adolphs, a social neuroscientist at the California Institute of Technology, calls the “complex and dynamic interplay between two opposing factors: on the one hand, groups can provide better security from predators, better mate choice and more reliable food; on the other hand, mates and food are available also to competitors from within the group.” You’re part of a team, but you’re competing with team members. Your teammates hope you’ll contribute skills and intergroup competitive spirit — without, however, offering too much competition within the group, or at least not cheating when you do. So, even if they like you, they constantly assess your trustworthiness. They know you can’t afford not to compete, and they worry you might do it sneakily.

if this leaves you curious for more, you can a) read the rest of the passage in the story at the Times site and/or b) read a new story in Scientific American about how gossip, so seemingly trivial, actually plays a vital role in managing our lives.

Excerpt below. Or go straight to The Science of Gossip: Why We Can't Stop Ourselves.


Only in the past decade or so have psychologists turned their attention toward the study of gossip, partially because it is difficult to define exactly what gossip is. Most researchers agree that the practice involves talk about people who are not present and that this talk is relaxed, informal and entertaining. Typically the topic of conversation also concerns information that we can make moral judgments about. Gossip appears to be pretty much the same wherever it takes place; gossip among co-workers is not qualitatively different from that among friends outside of work. Although everyone seems to detest a person who is known as a %u201Cgossip%u201D and few people would use that label to describe themselves, it is an exceedingly unusual individual who can walk away from a juicy story about one of his or her acquaintances, and all of us have firsthand experience with the difficulty of keeping spectacular news about someone else a secret.

Why does private information about other people represent such an irresistible temptation for us? In his book Grooming, Gossip, and the Evolution of Language (Harvard University Press, 1996), psychologist Robin Dunbar of the University of Liverpool in England suggested that gossip is a mechanism for bonding social groups together, analogous to the grooming that is found in primate groups. Sarah R. Wert, now at the University of Colorado at Boulder, and Peter Salovey of Yale University have proposed that gossip is one of the best tools that we have for comparing ourselves socially with others. The ultimate question, however, is, How did gossip come to serve these functions in the first place?

September 26, 2008

Minds of Babes, Agony of Defeat, Ocean Modeling, Oh MY

This week's Science is particularly rich in stories, it seems. These stories require a paid subscription, alas -- but the write-ups here, in Science's weekly mailing, make pretty good reading on their own for those without a subscription. My favorites:

From the Minds of Babes

I became fascinated with baby cognition when I did a story on Liz Spelke's work with infants while also raising a couple. Spelke and others have focused on the wee'ns's innate or very early powers of cognition, including numerosity and early logic and perception. Here, though, is an interesting study that proposes that at least one baby-logic error may occur not because baby's logic is poor but because baby is so intensely focused on being led socially by his or her playmate/mentor/teacher. Given the power and primacy of social connections and trust (a subject I took interest in while writing about Williams syndrome, this seems a viable hypothesis and a wonderful notion: I'd love to see it explored some more.

From Science:

Human babies between 8 months and a year of age cannot perform certain cognitive tasks. In one of these, called the A-not-B error, an object is hidden under a container and the infant repeatedly reaches for it. Then the experimenter hides the object under a different container, in full view of the infant, but the baby still looks under the first container to find it. Topál et al. (p. 1831) propose a new explanation for this error, suggesting that the socially intense "teaching" interaction that usually accompanies the repeated hiding of the object under the first container ensures strong association of the object with that location. When the object is hidden without any communication between the experimenter and the infant, the baby's error rate is reduced. Previous explanations for the phenomenon suggested that it was due to the immaturity of the infant's executive motor control or his or her limited cognitive capacities.

The Agony of Defeat

Maurice Delgado, formerly a post-doc at Liz Phelp's lab at NYU and now with his own at Rutgers, picks up one of the juicier fruits to fall from the neuroecon tree of late: the notion that people in auctions often bid less to experience the pleasure of winning (or owning) that to avoid the regret of losing.

From Science:


Auctioneers take advantage of human nature to increase the sale prices of items. But are they banking on the successful bidder's enjoyment of winning, or are they instead relying on the bidder's aversion to losing? Two sides of the same coin, one might say, but Delgado et al. (p. 1849; see the Perspective by Maskin) argue that it is the latter that drives the phenomenon known as overbidding. When participating in an auction, brain areas sensitive to loss became active. When the authors modified the ground rules of the auction so as to emphasize the potential for loss, without altering the basic possibility of winning, the tendency to overbid was magnified.

http://www.sciencemag.org/content/vol321/issue5897/twis.dtl

Modeling Ocean Circulation

I've loved ocean modeling since I spent way too much time looking at current models while writing The Great Gulf. A major challenge -- and a major need for modeling fish population dynamics, like whether zillions of cod larvae will grow to fish on Georges Bank or be swept into the abyss just to the south -- is modeling the currents in 3-D. Apparently someone has made progress on that front:

From Science:

Hydrothermal systems along ocean ridges help control the chemistry of the oceans and alter and hydrate the upper oceanic crust; this, in turn, returns water to the Earth's mantle at subduction zones. Hydrothermal systems also foster deep ocean ecosystems. Observations seem to indicate that although ocean ridges are broadly linear, outflows are spaced out along them. Comou et al. (p. 1825) have developed a three-dimensional numerical model of this flow to help reveal the dynamics. Their model shows that optimizing heat transfer causes the flows to self-organize into narrow pipe-like upflows, spaced about 500 m apart, fed by zones of warm downflow that recirculate up to a quarter of the heat.
Figure 1

Figure 2



Finally, for the part of you that loves cell phones and pure geekery:

Working Together to Get the Job Done

Bob tries to make a call to Alice but finds that the line is too noisy. Picking up his second phone (he's a very busy builder), he finds that line is also too noisy and so gives up trying to contact her. With two bad lines, Bob wouldn't be able to make that phone call, at least using the classical communication channels of his provider. Had he had access to quantum communication channels, Smith and Yard (p. 1812, published online 21 August; see the Perspective by Oppenheim) show theoretically that the situation is quite different. Two quantum channels, each with zero capacity to transmit information independently, will allow information to be carried across them when used together. Not only of theoretical interest, this counterintuitive result may be of practical use in the design of quantum communication networks.

(Can't be long before Clive Thompson is all over that one.)

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September 19, 2008

Why Bars Are So Loud

Direct from Mind Hacks: Loud Music Makes You Drink More:
PsyBlog has a delightful article discussing whether louder music increases alcohol consumption. It turns out it does, and surprisingly, there seems to have been quite a few studies done to examine the effect. One research group even did a sort of randomised controlled trial on bars and music in a fantastic real-world experiment. One study by Gueguen et al. (2004) found that higher sound levels lead to people drinking more. In a new study published in Alcoholism: Clinical & Experimental Research, Gueguen et al. (2008) visited a bar in the west of France to confirm their previous finding in a naturalistic setting. Here, they observed customers' drinking habits across three Saturday nights, in two different bars in the city. The level of the music was randomly manipulated to create the conditions of a true experiment. It was either at its usual volume of 72dB or turned up to 88dB. For comparison: 72db is like the sound of traffic on a busy street while 88db is like standing next to a lawnmower. Sure enough when the music went up the beers went down, faster. On average bar-goers took 14.5 minutes to finish a 250ml (8 oz) glass of draught beer when the music was at its normal level. But this came down to just 11.5 minutes when the music was turned up. As a result, on average, during their time in the bar each participant ordered one more drink in the loud music condition than in the normal music condition.